The accurate prediction of protein druggability (propensity to bind high-affinity drug-like small molecules) would greatly benefit the fields of chemical genomics and drug discovery.We have developed a novel approach to quantitatively assess protein druggability by computationally screening a fragment-like compound library.In analogy to NMR-based f
Nosocomial infections caused by microbial biofilm formation on biomaterial surfaces such as urinary catheters are complicated by antibiotic resistance, representing a common problem in hospitalized patients.Therefore, we aimed to modify silicone catheters to resist microbial adherence and biofilm formation by the tested microorganisms.This study us
This study aimed to carry out the cross-cultural adaptation of the Caregiver Reaction Assessment CRA for use in Brazil with informal caregivers of dependent elderly METHOD A methodological study, of five steps: initial translation, synthesis of translations, retro-translation, evaluation by a judge committee and a pre-test, with 30 informal alarecr
Untethered robots of the size of a few microns have attracted increasing attention for the potential to transform many aspects of manufacturing, medicine, health care, and bioengineering.Previously impenetrable environments have become available for high-resolution in merrick backcountry wet cat food situ and in vivo manipulations as the size of th